The mean PSA velocity of the men with cancer was 1.5 ng/mL per year. Of the total, 468 (25%) were diagnosed with prostate cancer, and 135 (7%) were diagnosed with prostatitis on their first biopsy. Most of the men underwent quadrant or sextant transrectal ultrasound-guided prostate biopsies, Dr.
Rapid jump on psa trial#
The study included 1,851 men enrolled in a community-based prostate cancer screening trial who had a non-suspicious digital rectal examination and a calculable PSA velocity, and had undergone their first prostate biopsy between 19. Men with a normal digital rectal exam, elevated PSA, and high PSA velocity should have a repeat PSA to confirm the elevated value, he said, and any symptoms or laboratory findings suggestive of prostatitis should prompt an appropriate evaluation and consideration of treatment. If it remains elevated, a biopsy to rule out cancer is warranted.” If there is nothing to suggest infection, we still recommend a repeat PSA to confirm the value. If infection is present, treat it as an infection and repeat the PSA. If it jumps dramatically, you should look to see if symptoms or urinalysis suggest infection. It warrants attention but doesn't mean that something is dramatically wrong. Eggener, MD: “A PSA rise is like a smoke alarm in the home. Eggener said that after the initial rapid rise in PSA, men with prostatitis will often have a significant drop in PSA in the year or two following biopsy. Speaking at the symposium, a meeting cosponsored by ASCO, ASTRO, the Prostate Cancer Foundation, and the Society of Urologic Oncology, Dr. Catalona, MD, Professor of Urology at Northwestern University Fienberg School of Medicine. Eggener, who performed the study with William J. Scott Eggener, MD, a urologic oncology fellow at Memorial Sloan-Kettering Cancer Center.īut men with a PSA velocity of 4.0 ng/mL per year or higher were just as likely to have prostatitis as they were to have prostate cancer, said Dr. In a study of 1,851 men, those with a modest rise in PSA of less than 2.0 ng/mL per year had a significantly increased risk of prostate cancer, said E.
SAN FRANCISCO-Prostatitis can cause serum PSA levels to shoot up, a finding that needs to be taken into account when using PSA velocity for prostate cancer detection, according to data presented here at the Prostate Cancer Symposium.
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